NG

NICE NG131

Prostate Cancer Guide

Hormone Therapy Management

Guidance on managing side effects and monitoring patients receiving hormone therapy.

Key Recommendations

Side Effects Management (1.4.1)

Offer people having hormone therapy advice on managing these common side effects:

  • • Hot flushes
  • • Sexual dysfunction
  • • Fatigue
  • • Osteoporosis

Osteoporosis Risk Assessment (1.4.2)

Follow the recommendations in the NICE guideline on osteoporosis: assessing the risk of fragility fracture when assessing the risk of fragility fracture in people having hormone therapy.

Prescribing Guidance (1.4.3)

Follow the recommendations in NICE's guidance on prescribing medicines when prescribing medicines for the side effects of hormone therapy.

Managing Common Side Effects

1

Hot Flushes

Sudden episodes of flushing and sweating

Management: Counseling on triggers, consider pharmacological options

2

Sexual Dysfunction

Erectile dysfunction and reduced libido

Management: Psychosexual support, consider PDE5 inhibitors

3

Fatigue

Persistent tiredness and reduced energy

Management: Lifestyle modifications, exercise programs

4

Osteoporosis

Reduced bone density and fracture risk

Management: DEXA scans, calcium/vitamin D, consider bisphosphonates

GP Role in Hormone Therapy Management

As a GP, your role includes:

  • Monitoring: Regular review of side effects and treatment tolerance
  • Support: Provide counseling and reassurance about common side effects
  • Osteoporosis Screening: Arrange DEXA scans as indicated by risk assessment
  • Medication Management: Prescribe supportive medications for side effects (e.g., PDE5 inhibitors, bisphosphonates)
  • Liaison: Maintain communication with specialist services regarding treatment changes
  • Psychosexual Support: Offer or refer for specialized psychosexual counseling when needed

Important: Hormone therapy side effects can significantly impact quality of life. Early identification and management improve patient satisfaction and treatment adherence.

Osteoporosis Prevention

Key Actions for GPs

  • • Assess baseline fracture risk using NICE osteoporosis guidance
  • • Recommend calcium intake (1000-1200 mg/day) and vitamin D supplementation
  • • Encourage weight-bearing exercise and muscle strengthening
  • • Consider DEXA scanning for patients at high risk
  • • Prescribe bisphosphonates if indicated (e.g., alendronate)
  • • Monitor for medication side effects (e.g., GI upset from bisphosphonates)